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Valecobulin hydrochloride

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COA HPLC HNMR

Valecobulin hydrochloride

Catalog No. T13278Cas No. 1240321-53-2

Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.

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Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock

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Product Introduction

Bioactivity

Description	Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.
In vivo	In various human tumor xenograft models,Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; In male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy [1].
Alias	CKD-516 hydrochloride

Chemical Properties

Molecular Weight	573.06
Formula	C26H29ClN6O5S
Cas No.	1240321-53-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (218.13 mM)

H2O: 50 mg/mL (87.25 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.7450 mL	8.7251 mL	17.4502 mL	87.2509 mL
5 mM	0.3490 mL	1.7450 mL	3.4900 mL	17.4502 mL
10 mM	0.1745 mL	0.8725 mL	1.7450 mL	8.7251 mL
20 mM	0.0873 mL	0.4363 mL	0.8725 mL	4.3625 mL
50 mM	0.0349 mL	0.1745 mL	0.3490 mL	1.7450 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0175 mL	0.0873 mL	0.1745 mL	0.8725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc